Production of transgenic animals pdf

The main principle in the production of transgenic animals is the introduction of a foreign gene or genes into an animal the inserted genes are called transgenes the foreign genes must be transmitted through the germ line so that every cell including germ cells of the animal contains the same modified genetic material 18. Transgenic animals for the production of therapeutic and diagnostic proteins are produced by transferring fertilized transgene carrying embryos to recipient animals. A transgenic animal is one that carries a foreign gene that has been deliberately inserted into its genome. Transgenesis is the process by which mixing up of genes takes place. By damaris benny daniel ii msc. Usually ear tissue and blood are screened by polymerase chain reaction and or southern analysis for the presence of the transgene. Telos is defined as the set of drugs from transgenic animals in clinical needs and interests which are genetically based trials environmentally expressed and which collectively the approval of atryn ratiii by usfda has constitute or define the form of life or way of opened gates for other drugs from transgenic living exhibited by that animal and whose animals. Foreign genes are inserted into the germ line of the animal so it can be transmitted to the progeny. This promise has been realized in many areas with the exception of production of transgenic livestock with rigorously demonstrated superior production characteristics. The production of transgenic animals has focused mainly on producing models e g the mouse for basic and medical research. Methods for producing transgenic animals. To produce a transgenic animal a segment of dna or expression vector is figure 1. The transgenic production process a transgenic animal is an animal whose cells incorporate sequences of dna that are not normally part of its genome. Until recently pronuclear microinjection of deoxyribonucleic acid dna was the standard method for producing transgenic animals. The advent of transgenic animal technology nearly 20 yr ago carried with it promise for biomedical research pharmaceutical production in animal systems and enhancement of food animal production.

The transgenic livestock can be useful for the production of disease resistant animals pigs for xenotranplantation animal bioreactor for therapeutic recombinant proteins and disease model animals. Following natural gestation and birth offspring are subject to tissue biopsy and blood sampling. Transgenic animals have the potential of agricultural applications like improved growth rate and carcass composition improved resistance to disease increased milk yield improved wool production. To date gtc has produced 50 diverse proteins in the milk of transgenic. Transgenic farm animals have also become important in human medicine as sources of biologically active proteins as donors in xenotransplantation for research in cell and gene therapy and for human disease modeling.

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